Immunology: Contrasuppressor cells and oral tolerance
نویسندگان
چکیده
منابع مشابه
Immunology of the gut and oral tolerance
The gastrointestinal tract has developed a unique immunological system because of its close proximity to the intestinal contents. The system has evolved in such a way that it does not respond to the presence of beneficial microbes, but retains the ability to react quickly to the presence of harmful organisms. The challenge faced by the mucosal immune system is to generate an immune response of ...
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The mucosal surfaces of the gastrointestinal and respiratory tracts represent the principal portals of entry for most infectious agents. Hence, the development of vaccination strategies capable of inducing protective immune responses at the mucosal sites is a priority. Since the mucosal surfaces are exposed to a wide variety of antigens, the mucosal immune system has to discriminate between har...
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Oral tolerance prevents oral sensitization to dietary antigens (Ags), including proteins and haptens, and development of delayed-type hypersensitivity (DTH) responses. We showed here that plasmacytoid dendritic cells (pDCs) prevented oral T cell priming and were responsible for systemic tolerance to CD4(+) and CD8(+) T cell-mediated DTH responses induced by Ag feeding. Systemic depletion of pDC...
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The immune system is continuously exposed to great amounts of different antigens from both food and intestinal microbes. Immune tolerance to these antigens is very important for intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by exposure to antigen via the oral route. Investigations on the role of intestinal immune system in preventi...
متن کاملOral mucosal immunology: an overview.
The primary function of the immune system of the mouth is to protect the teeth, jaws, gingivae and oral mucosa against infection. These host defences vary in the different oral microenvironments or domains represented by the oral mucosa, saliva and gingival crevice. This review aims to consider and contrast the main immune components in each domain and cites examples of oral diseases where the ...
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/320398a0